Other articles where fluphenazine decanoate is discussed. Send the page to a friend, relative, colleague or yourself. Available as fluphenazine hydrochloride or fluphenazine decanoate. Fluphenazine injection stays in your body longer than the oral form, and the injections are not given daily.
Fluphenazine daviss drug guide for rehabilitation professionals. Fluphenazine decanoate 5002471 25 mgml benzyl alcohol 100516 12 mgml fluphenazine decanoate injection, usp fresenius kabi usa, llc. Fluphenazine decanoate exerts its actions by blocking postsynaptic dopamine d2 receptors in the limbic, cortical system and basal ganglia. Fluphenazine hydrochloride has not been shown effective in the management of behavioral. Fluphenazine decanoate injection, usp is available as a clear, pale yellow solution for intramuscular im or subcutaneous sc use providing 25 mg fluphenazine decanoate per ml in a sesame oil vehicle with 12 mg benzyl alcohol as a preservative. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and. See full prescribing information pdf acknowledgements. Fluphenazine injection is injected into a muscle or under the skin by a healthcare provider. Fluphenazine decanoate section after pearls for dosing and use continued fluphenazine 291 pharmacokinetics mean halflife of oral formulation approximately 15 hours mean halflife of intramuscular formulation approximately 6. Dec 18, 2017 for psychotic patients who have been stabilized on a fixed daily dosage of orally administered fluphenazine hydrochloride dosage forms, conversion to the longacting injectable fluphenazine decanoate may be indicated see package insert for fluphenazine decanoate injection for conversion information.
Modecate, modecate concentrate fluphenazine dosing. Fluphenazine hydrochloride injection, usp package insert. To begin therapy with fluphenazine decanoate injection the following regimens are suggested. It works by changing the actions of chemicals in your brain.
Capitals indicate lifethreatening, underlines indicate most frequent. Fluphenazine decanoate is dissolved in sesame oil for long duration of action. Fluphenazine decanoate injection multipledose vial. Fluphenazine decanoate timing of administration for people with. In the present study, we treated rats with either vehicle or fluphenazine decanoate 5 mgkg, im every 2 weeks for 4, 8 or 12 months. It is used in the treatment of chronic psychoses such as schizophrenia, and appears to be about equal in effectiveness to lowpotency antipsychotics like chlorpromazine.
Contraindications for fluphenazine decanoate injection. Fluphenazine decanoate medicinal forms bnf content. Fluphenazine decanoate injection auromedics pharma llc. Each ml of haldol decanoate haloperidol decanoate 50 for im injection contains 50 mg haloperidol present as haloperidol decanoate 70. The pharmacology, administration, comparative side effects and treatment of schizophrenia with standard nonlai antipsychotics are. Neurological disease, parkinsons disease antipsychotics can cause motor and sensory instability, which may lead to falls with the potential for fractures and other injuries.
The decanoate salt form of fluphenazine, a phenothiazine with antipsychotic activity. Fluphenazine decanoate injection, usp package insert fluphenazine decanoate injection, usp 25 mgml rx only description fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. To begin therapy with fluphenazine decanoate injection, the following regimens are suggested. Administer im or subq using a dry syringe and needle of at least 21 gauge. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the. Fluphenazine decanoate timing of administration for people with schizophrenia. Fluphenazine is usually given by injection only after you have taken the medicine by mouth for a certain period of time. Fluphenazine decanoate drug bnf content published by nice. The effects of fluphenazine decanoate are the same as those of fluphenazine hcl.
Fluphenazine decanoate injection, usp package insert. Im or subcutaneous sc use providing 25 mg fluphenazine decanoate per ml. It is given by mouth, injection into a muscle, or just under the skin. Fluphenazine decanoate injection, usp 25 mgml, initially with a. Injection, fluphenazine decanoate, up to 25 mg drugs administered other than oral method, chemotherapy drugs j2680 is a valid 2020 hcpcs code for injection, fluphenazine decanoate, up to 25 mg or just fluphenazine decanoate 25 mg for short, used in medical care. Fluphenazine decanoate is not indicated for the management of severely agitated psychotic patients, psychoneurotic patients or geriatric patients with confusion andor agitation. Fluphenazine decanoate drug bnf content published by. Use our prescription price comparison tool to find the best prescription drug price for fluphenazine decanoate in your area, then use our prescription discount card to save even more. Patients who have shown hypersensitivity to other phenothiazines, including fluphenazine, should not be given fluphenazine decanoate.
Dec 10, 2018 fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. Fresenius kabis health hazard evaluation concluded that the oos assay value observed is unlikely to be clinically significant. For psychotic patients who have been stabilized on a fixed daily dosage of orally administered fluphenazine hydrochloride dosage forms, conversion to the longacting injectable fluphenazine decanoate may be indicated see package insert for fluphenazine decanoate injection for conversion information. Fluphenazine side effects, dosage, interactions drugs. Fluphenazine decanoate full prescribing information. Webmd provides common contraindications for fluphenazine decanoate injection. Fluphenazine decanoate injection, usp is a sterile injection, available for intramuscular or subcutaneous administration, providing 25 mg fluphenazine decanoate per ml. It is a highly potent behavior modifier with a markedly extended dura tion of effect and has the following structural formula. Fluphenazine, sold under the brand names prolixin among others, is an antipsychotic medication. Seventeen outpatients were treated with depot neuroleptics, zuclopenthixol decanoate in viscoleo or fluphenazine decanoate in sesame oil, with dosage intervals of 3 weeks. Dailymed fluphenazine hydrochloride solution, concentrate. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were determined by high performance liquid. Fluphenazine decanoate dihydrochloride united states. Relative bioavailability and safety of aripiprazole lauroxil, a novel oncemonthly, longacting injectable atypical antipsychotic, following deltoid and gluteal administration in adult subjects with schizophrenia.
Empirical formula hill notation c 32 h 44 f 3 n 3 o 2 s 2hcl. Prolixin decanoate fluphenazine decanoate fda package. Fluphenazine decanoate injection may be given im or sc. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy eg, chronic schizophrenics. Although striatal pathologic changes are believed to underlie this potentially irreversible iatrogenic syndrome, the nature of the neurolepticinduced neuropathology is unclear. Fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. Fluphenazine decanoate drug information email this page. Fluphenazine decanoate information, side effects, warnings. A dry syringe and needle of at least 21 gauge should be used. Although the mode of action is unknown, antagonism of dopaminemediated central synaptic transmission may be the primary action through which. This medication is given by injection into a muscle intramuscularlyim or beneath the skin subcutaneouslysubq by a nurse or doctor. Most of the deaths were linked to heart disease or infection. Fluphenazine is an antipsychotic medicine in a group of drugs called phenothiazines feenohthyeazeens. We collected data on hdlai prescription and administration from patient notes and prescription charts for patients each time the depot was due.
Fluphenazine decanoate is an ester of fluphenazine. Permitil, prolixin fluphenazine uses, side effects, dosage. Fluphenazine decanoate is 2432trifluoromethylphenothiazin10ylpropylpiperazin1ylethyl decanoate. Fluphenazine decanoate injection, usp is a sterile injection, available for intramuscular or subcutaneous administration, providing 25 mg fluphenazine decanoate per ml in a sesame oil vehicle with 1. We do not record any personal information entered above. Fluphenazine and fluphenazine decanoate patient education. Comparative study of the pharmacokinetics of zuclopenthixol. Fluphenazine decanoate dihydrochloride united states pharmacopeia usp reference standard cas number 2376650. Fluphenazine decanoate fluphenazine decanoate dose.
Haldol haloperidol is less likely to cause weight gain and sedation, but more likely to cause movement disorders compared to other antipsychotics. A randomized clinical trial of haloperidol decanoate and flu. Fluphenazine hydrochloride is indicated in the management of manifestations of psychotic disorders. Prolixin decanoate fluphenazine decanoate is longacting medicine for stabilizing your mood that must be given by a trained healthcare professional. Fluphenazine hydrochloride monograph for professionals. Psychiatryonline subscription options offer access to the dsm5 library, books, journals, cme, and patient resources. Labelingpackage insert label is not available on this site. Nov 09, 2018 fluphenazine is an antipsychotic medicine in a group of drugs called phenothiazines feenohthyeazeens. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy e. Fluphenazine decanoate fda orange book approved drug. Fluphenazine decanoate prescription price comparison. Fluphenazine decanoate injection has not been shown effective in the management of behavioral complications in.
Haloperidol decanoate is almost insoluble in water 0. This medication is given by injection into a muscle intramuscularlyim or beneath the skin subcutaneouslysubq by a. Fluphenazine decanoate injection is a sterile solution of fluphenazine decanoate in a suitable vegetable oil. It is a highly potent behavior modifier with a markedly extended duration of effect. Fluphenazine decanoate and fluphenazine enanthate are depot injection formulations should not be utilized in patients with hepatic impairment. Fluphenazine decanoate injection, usp is available as a clear, pale yellow solution for intramuscular appropriate dosage. Neurological disease, parkinsons disease antipsychotics can cause motor and sensory instability, which may lead to. The ester is slowly absorbed from the intramuscular site of injection, and is then hydrolysed in the plasma to the active agent, fluphenazine. Please enter valid email address recipients email is required. Fluphenazine decanoate is available as an lai in sesame oil. During the 4th, 6th, and 8th dosage interval blood samples were drawn in oxalated tubes. J2680 hcpcs code for injection, fluphenazine decanoate, up. Haldol decanoate 50 haloperidol haldol decanoate 100. Modecate concentrate, pmsfluphenazine, prolixin, prolixin decanoate.
Use of a wet needle or syringe may cause the solution to become cloudy. Administration of haloperidol decanoate in sesame oil results in slow and. Fluphenazine decanoate injection is a longacting parenteral antipsychotic drug intended for use in the management of patients. Ndc proprietary name nonproprietary name dosage form route name company name product type. Find out what health conditions may be a health risk when taken with fluphenazine decanoate injection. The most characteristic effect of intravenous etomidate on the respiratory system is a slight elevation in arterial carbon dioxide tension paco. Fresenius kabi recall of fluphenazine decanoate injection.
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